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Collectively, these mechanisms complement the epigenetic and molecular regulatory network, providing a more integrated understanding of ferroptosis in VSMCs as depicted in Fig

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showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]